- Title
- Towards a framework for better understanding of quiescent cancer cells
- Creator
- Nabil, Wan Najbah Nik; Xi, Zhichao; Song, Zejia; Jin, Lei; Zhang, Xu Dong; Zhou, Hua; De Souza, Paul; Dong, Qihan; Xu, Hongxi
- Relation
- Cells Vol. 10, Issue 3, no. 562
- Publisher Link
- http://dx.doi.org/10.3390/cells10030562
- Publisher
- MDPI AG
- Resource Type
- journal article
- Date
- 2021
- Description
- Quiescent cancer cells (QCCs) are cancer cells that are reversibly suspended in G0 phase with the ability to re-enter the cell cycle and initiate tumor growth, and, ultimately, cancer recurrence and metastasis. QCCs are also therapeutically challenging due to their resistance to most conventional cancer treatments that selectively act on proliferating cells. Considering the significant impact of QCCs on cancer progression and treatment, better understanding of appropriate experimental models, and the evaluation of QCCs are key questions in the field that have direct influence on potential pharmacological interventions. Here, this review focuses on existing and emerging preclinical models and detection methods for QCCs and discusses their respective features and scope for application. By providing a framework for selecting appropriate experimental models and investigative methods, the identification of the key players that regulate the survival and activation of QCCs and the development of more effective QCC-targeting therapeutic agents may mitigate the consequences of QCCs.
- Subject
- quiescence; dormancy; cancer; model; detection; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1455962
- Identifier
- uon:45157
- Identifier
- ISSN:2073-4409
- Rights
- © This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Language
- eng
- Full Text
- Reviewed
- Hits: 3182
- Visitors: 3351
- Downloads: 178
Collections
Goal 3: Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 1007 KB | Adobe Acrobat PDF | View Details Download |